Sentence examples for may have downregulated from inspiring English sources

We then hypothesised that the high accumulation of IL-6 may have downregulated Mage-b-specific immune responses at the site of the primary tumour.

Whilst DENV-1 immunity did not appear to prevent DENV-2 infections, partial immunity may have downregulated infections, thus reducing severity to mild disease during secondary dengue infections.

Thus, we think that the EAE may have downregulated MMP-9 protein expression and upregulated nm-23H1 in HCC in vivo; the more reduced the MMP-9 protein expression the less degraded the extracellular matrix; cancer cell migration and invasion were suppressed, the same effect as nm23-H1 increased in HCC.

These results suggest that RA may indeed have downregulated the genes involved in adhesion and migration.

In addition, our data support the argument that tumors having downregulated CXCR4 may be less responsive to the endogenous and/or exogenous SDF-1 α compromising the antitumor activity of SDF-1 α.

By contrast, subjects with BD-I did not show any differences in DLPFC amygdala functional connectivity relative to HC, but did show increased activity in these regions during the presence of fear distracters, suggesting an increased emotional reactivity that may have been inefficiently downregulated.

One study suggests that CD69 may have a role in downregulating immune responses through TGF-γ [59].

This observation indicates that the transcriptional repressor role of SerRS is ultimately through SIRT2 and that the direct blocking of c-Myc from the promoter by SerRS may have lesser significance for downregulating gene expression.

Possibly due to Pol II pausing or slow progression immediately downstream of the TIS [29], nucleosomes or potential agents anchoring them in the 5' untranslated region and in the first third of the coding region may have the strongest role in downregulating transcription.

Downregulated proliferation may have contributed to slight but not pronounced induction of apoptosis resistance in response to continuous treatment with cabozantinib as general agreement exists that cytotoxicity of anticancer agents is proliferation-dependent.

Therefore, inhibition of TOPK at this level of signalling may have a more significant impact on downregulating deregulated ERK/MAPK signalling.