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People with autism, have a strong family history of schizophrenia and bipolar disorder [1], [2], [3] and may have alterations in the same set of genes [4], [5].
The other 15%, defined as 'wild type', may have alterations in BRAF, IGFR-1 and succinate dehydrogenase (Corless et al, 2011).
Patients with severe renal impairment may have alterations in gastrointestinal transit time or bacterial overgrowth in the gastrointestinal tract that may affect drug absorption [ 17, 18].
We hypothesised that adult patients with type 1 diabetes may have alterations in subjective sleep characteristics, assessed by validated sleep questionnaires, compared with healthy controls.
The GPI-AP Hemojuvelin also regulates Hepcidin, so gnz and bkr mutants may have alterations in the function of genes that regulate iron levels.
Also, diabetic patients may have alterations in hepatocyte expression of surface receptors such as insulin receptor or insulin-like growth factor receptor that increase susceptibility to unidentified tumor promoting factors.
Similar(53)
These HIV-exposed uninfected (HEU) infants may have immunological alterations which could lead to weakened responses to infections and vaccines and vulnerability to disease [ 7].
This suggests that very small differences in the airway pressures (as small as 1 cmH2O in this study) may have dramatic alterations in lung recruitment.
On the other hand, some genes, for example, those related to insulin secretion, may have obtained alterations in promoter methylation much earlier.
Flow sorting for pools of double-positive cells has yielded excellent results and avoids potential problems with using clonal populations that may have other alterations introduced or perpetuated by the cloning and selection process.
Although the p53-negative cell line HCT116 cell line is derived from the p53-positive one and should thus have the same genotype apart from p53, both cell lines may have acquired alterations later on, which may result in a different behaviour.
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