In order to define candidate regions that may harbor specific genes relevant to breast cancer development, we identified the smallest aUPD regions at chromosome 3p21.31 (TUSEMA3FEMA3F, SEMA3B, RASSF1, MAPKAPK3, HYAL1, HYAL2, FUS), 3p26.2-p26.1 (LRRN1, SETMAR, SUMF1), 3p26.1 (GRM7), 11q22.3 (CASP, CASP4, CASP5, CASP12, COP1, CARD16, CARD18, GRIA4) (Table 3) in TN breast cancer samples.
SELDI-TOF may add insight into those proteins that are expressed in serum, blood, saliva, urine or any other biological material that may harbor specific markers for typhoid infections.
We have not found genomic alterations universally present in all (100%) three subgroups of NBs, although such a region would be interesting since it may harbor specific genes that are uniquely responsible for NB tumorigenesis.
Depending on host factors, patients eliminate T. whipplei and may harbor specific antibodies; carry it chronically for at least 5 years (D. Raoult, unpub. data) while exhibiting strong immune responses; or suffer from subacute or chronic infections, including classic Whipple disease without mainly developing antibody response.
The multiple alignments showed the existence of nine large locally colinear blocks (LCBs); however, it was observed that strain-specific regions were also present within LCBs (white segments in Additional file 1), which may harbor specific adaptations of each bacterium, as it will be further discussed in the plasticity segment section.
The goal of the present work was to investigate whether natural yeast strains may harbor specific alleles, e.g. in structural and/or regulatory genes of glycerol metabolism, that would allow reducing the glycerol yield and increasing the ethanol yield in yeast fermentation without causing negative side-effects on other essential functions.
Human recombination hotspots, and chimpanzee genomic regions syntenic to human recombination hotspots, may harbor-specific sequence features that are associated with high levels of DNA methylation.
Critically ill patients may harbor ICU-specific characteristics that predispose to failure of thrombo-prophylaxis.
This is somewhat akin to the human situation wherein patients may harbor AQP4-specific serum antibodies for many years without showing clinical signs of NMO 41.
Divergent regions between the two genomes are also of interest because they may harbor species-specific genes that are ecologically important in soil and beehive environments, respectively.
The wide distribution of Mx members in various environments and the fact they are not evolutionarily affiliated to any other previously known methanogenic order may suggest that they harbor specific characteristics.
