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This in turn may hamper detection of physical function differences in older age, because those surviving are not representative of the sub-population of women who gave birth as adolescents.
The prevalence of normal DNA and the large dilution of free tumor DNA by normal DNA may hamper detection of genetic alterations in blood as discussed by several laboratories for other tumor entities [ 29- 32].
Recent studies have demonstrated that, although imaging of clinical and subclinical arthritis with (R -[C]PK11195 PET is pR -[C]PK11195siderable background uPETke of the tracer is promisingconsiderables (in particular backgroundmarrow) may hamper detection of suptakechanges in macrofhage infilthetracernd inflammation [ 3, 9].
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On the other hand, some studies underline the possibility that distension of the lumen and the subsequent compression on the mesorectum may hamper the detection of perirectal lymph nodes and lead to overestimation of the mesorectal fascia infiltration [8].
In abdominal tumor models, a moderate-to-high physiological uptake in the gut is observed with many tracers, including 18F]fluorodeoxyglucose (18F-FDG) and 18F]fluorothymidine (18F-FLT), which may hamper tumor detection.
We note that this approach may affect the comparison of Model A and B in BayesTraits as an incorrect root node may hamper the detection of trait evolution, hence we repeated our analyses assigning another arbitrary individual bearing the most common haplotype to the root node and checked for concordance of results.
This may hamper computational detection of relevant patterns for neutral variants.
Somatic hypermutations are characteristic of MM and they may hamper clonality detection, sequencing success and ASO performance.
Furthermore, the difficulties in differentiating small nodal metastases may hamper the detection of small contralateral or skip metastases.
For instance, when clearance from the blood is low, non-specific signal from circulating tracer may hamper the detection and quantification of the specific signal from beta cells.
An excess of human DNA may hamper the detection of pathogen genomic material or may inhibit the PCR reaction [ 18, 19]; hemoglobin traces may also inhibit PCR-based amplification.
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