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The resulting loops were shorter, which ablated any analogue of antigenic site A and may hamper binding of the VLDL-R molecule, the only LDLR family member with a well-defined footprint.
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Our results may indicate a threshold effect, since there is no discernible decrease in birth weight below a maternal PCB concentration of less than 25 μg / L. Assuming an endocrine mode of interference of PCB, a threshold effect is plausible since PCB may hamper the binding of hormones to their receptors [ 52].
Although recent studies indicate that UCN-01 binds to the human serum protein alpha1-acid glycoprotein and that this binding may hamper the ability of UCN-01 to inhibit cell proliferation and kill cells in vivo, UCN-01 has decent activity against several tumours at dose levels that are tolerated in clinical studies [ 27, 28].
The balance between these requirements is complex: While a low degree of difference from the parent peptide supports good binding properties, it may hamper bioavailabilty.
The methionine filter removes combinations with epitopes containing methionine (symbol M ), since chemical modifications of methionine may hamper the recognition of the target epitope by a binding molecule, especially by an antibody.
Because specimens were not heat-denatured and because primate sperm PH-20 has a HA binding domain that is distinct from the hyaluronidase domain [ 17, 31], we hypothesized that the binding of high-molecular-weight HA molecules to the PH-20 molecules may hamper the protein's movement to its expected location.
That may hamper recruiting.
His personal style may hamper systematic government.
Banks are facing stricter capital requirements that may hamper interest in the assets from rival firms.
Such conditions may hamper innovation.
That may hamper patient safety efforts.
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