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Taken together, the unique molecular and clinical characteristics of PT-DLBCL have informed on aspects of the distinct disease biology of this organotypic lymphoma that may guide rational therapeutic strategies.
We have discerned certain phenotypes that contribute to cell death, which may guide rational development of these drugs or formulation of synergistic drug combinations to enhance chemotherapeutic efficacy.
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The quantitative framework presented here may help guide rational design of future clinical studies using lampalizumab.
Anatomically accurate high-resolution MRI-based forward-models may guide the "rational" clinical design and optimization of tDCS.
The analysis about the structure property relationship may guide the rational design and evaluation of photovoltaic materials and device structures.
Approaches for temporal and spatial control are further described to illustrate principles that may guide integrated rational design of 3D scaffolds.
If a (glyco peptide surpasses the inhibitory potency of the free sugar, then the new peptide lectin contacts underlying the affinity enhancement may guide further rational drug design.
The description of these structure property correlations may guide the rational design of polymer structures and the reasonable evaluation of their photovoltaic performance.
The findings demonstrate that the introduction of n-type ILs is effective in developing high-performance hybrid WOLEDs, which may guide the rational design of both the material and device structure of WOLEDs in emerging display and lighting applications.
Thus, the data presented here may guide the rational design of new agents with different DNA binding properties and/or a cytotoxic profile by isosteric substitution of known intercalators.
Such information on patterns of antimicrobial resistance is an effective mean to guide rational treatment [ 4].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com