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Moreover, ERK1/2 may govern cell movement by phosphorylating the myosin light-chain kinase, the protease calpain, or the focal adhesion kinase.
Could this be the time of greatest vulnerability, as this is the time when protein synthesis and accumulation in G1 may govern cell fate decisions?
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Further experiments demonstrated that Notch directly regulates the expression of the BMI1 gene in T cells and may govern T cell proliferation through this pathway.
Despite the increasing evidence of anomalies in the bone marrow microenvironment of hematologic malignancies, which may govern stem cell activity and lead to disease (reviewed in [ 12, 13]), knowledge about the role of inflammation in leukemogenesis is scarce.
Because we were able to identify immunogenic DR4 restricted peptides using this model, we wished to study the rules that may govern T-cell cross-reactivity and molecular mimicry.
Trop-2 has been shown to directly mediate tumor-associated calcium-mediated signal cascades [ 39] and activation of ERK 1/2-MAPK pathways [ 36], both of which govern cell cycle progression [ 40, 41] and may protect cancer cells from apoptosis [ 42].
Alternatively, the mechanisms that govern cell death between the naive and primed states of pluripotency may differ.
Besides these genetic abnormalities, also epigenetic alterations in the expression of critical genes may occur during cancer progression, and these changes are reflected in the signalling pathways that govern cell proliferation, cell migration, dormancy, and chemoresistance.
In the mid-1980's, he turned his attention to cell biology, studying how genes govern cell division.
Likewise, the same genetic pathways that govern cell size control in normal development also govern renal hypertrophy [ 152, 153].
Together, these data suggest that a certain extent of surface expression on healthy tissue may not necessarily result in toxic side effects against nonmalignant tissue and the metabolic state/activation status of a target cell may govern its susceptibility to immunotoxin action.
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CEO of Professional Science Editing for Scientists @ prosciediting.com