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CORMs too may generate oxidative stress (51, 67).
An increase in the plasma copper concentration has also been reported in women with established preeclampsia and this may generate oxidative stress by catalyzing the synthesis of reactive oxygen species (ROS) [20,21].
By knowing the fact that the flavonoids may act as prooxidant and may generate oxidative stress which might be the reason for hepatotoxicity, we examined the activity and expression of major antioxidant enzymes.
On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response.
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In conclusion, chronic SM exposure may have the potential to generate oxidative stress which may trigger the release of cytochrome c as well as caspase-3 activation in neurons leading to cell death by apoptosis in a dose dependent manner which may in the end be responsible for the disruption of cognitive functions in mice.
In this manner, sepiapterin may generate an oxidative environment in the Air arteries that is partially NOS driven, similar to the effects of DE exposure.
Under biotic or abiotic stress, ROS may dramatically accumulate in plants and generate oxidative damage (Faltin et al. 2010; Gill and Tuteja 2010; Suzuki et al. 2011).
In aprotic medium, the compound exhibits reactivity with O2 at an apparent constant of 0.45 s−1 and its mechanism of action may be associated the ability to generate oxidative stress.
Contrary to this, previous studies have reported that CeO2 NPs generate oxidative stress and may induce apoptosis in human lung epithelial cells [ 16, 17].
Taken together, these data suggest that the deleterious effect of THC on brain mitochondria could be linked to its ability to generate oxidative stress and that this mechanism may be involved in young cannabis users who develop a stroke.
17, 18 Furthermore, Aβ peptides generate oxidative stress via neuroinflammation.
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