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Moreover, the presence of NRPS could offer further genetic modifications, which may generate novel genetically modified peptides in the future with high pharmacological importance.
Using these model networks as the basis, one may generate novel networks by introducing a few random links whereby the local properties are preserved while the desired global properties are approximated.
The resulting recombinant genome may generate novel phenotypic traits.
Re-analysis of publicly available CLIP-seq data may generate novel hypotheses.
Both whole and partial chromosome loss is observed, which may generate novel chromosomes.
Our findings may generate novel perspectives on the progress and prognosis of cirrhosis.
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Intergenic SVs associated with the coding regions of genes also have the potential to alter the expression levels (e.g., the 5′ partner gene typically provides the promoter region in addition to 5′ coding sequences while the 3′ partner may bring novel microRNA binding sites in its 3′ UTR) but may also generate novel fusion proteins if reading frames are maintained.
These studies will help to interpret and validate our findings derived from epidemiologic research, while our findings may help generate novel hypotheses to be tested in animal models.
The molecular dissection of the rhesus spermatogenic lineage presented in this study provides a contemporary perspective for interpreting old and new experimental results and may help generate novel hypotheses about the biology and regenerative capacity of primate SSCs.
We hypothesized that conjugation of a metal chelator to destabilize Aβ fibrils (fAβs) and a long-chain fatty alcohol to induce neurite outgrowth may generate a novel molecular scaffold that targets both pathologies.
In addition, it may be possible to generate novel MDV-1 vaccines based on the BACs.
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