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Such a mechanism may generate genomic differences and differential mosaicism in most or all individuals.
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At least some of these polymorphisms may in themselves generate genomic instability in susceptible individuals, as at least some MCM polymorphisms cause genomic instability when assayed in budding yeast [ 88].
It is also important to address other potential cellular events that may generate IAV genomic mutations during viral life cycle.
This relatively high frequency may reflect that the loss of a high-fidelity DNA repair pathway can generate genomic instability that is an enabling characteristic of cancer (Hanahan and Weinberg, 2011).
Second, each genomic locus may generate several types of transcripts, either because of genomic variants (i.e. there may exist several alleles for a locus) or because of transcriptomic variants (i.e. alternative splicing or alternative transcription start/end may generate several transcripts from a single locus that differ by the inclusion or exclusion of subsequences).
It seems likely that the genes contained in genomic islands may generate unique phenotypes and affect bacterial fitness, such as the interaction of bacterial cells with their surrounding environment.
Types of arrays and the data they collect are addressed, as are the types of results that array comparative genomic hybridization studies may generate.
However, genome rearrangements were observed both between and within species, conferring high genomic plasticity, which may generate environmental adaptability and contribute to differences in symbiotic performance.
We also discuss the role transposable elements may have had in generating genomic variation and a potential link between transposable element proliferation and patterns of speciation.
Our data further supports the hypothesis that they may be selected for generating genomic variability in response to environmental stimuli, since they were affected differently in wine and clinical strains.
These phenomena show that drugs with high genomic relatedness and chemical similarity may generate different therapeutic effects (block b and d), and drugs with diverse structures could still have a similar therapeutic activity and related targets (block c).
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