Indeed, physiologic cues, such as ageing and diet, and pathologic conditions, which include lysosomal storage diseases (LSDs), neurodegenerative diseases, injuries, and infections may generate an adaptive response of the lysosome (Luzio et al, 2007; Ballabio and Gieselmann, 2009; Saftig and Klumperman, 2009).
Given that regions of high mutation rate may be more likely to generate adaptive variation that can be selected in natural isolates, these results underscore the importance of accounting for heterogeneity in mutation rates across the genome when interpreting patterns of parallel evolution.
Certainly aneuploidy is beneficial in the response to stress in other fungi, and both aneuploidy and polyploidy may provide mechanisms for cells to generate adaptive variability and deal with environmental challenges [ 13, 15, 59- 63].
Therefore, our data suggest that risk accrues for MTS patients whose TLE develops in adulthood, because the mature, injured brain may have lost its capacity to generate adaptive mechanisms to compensate for the deleterious effect of TLE on brain network organization.
Protein dynamics generate adaptive cellular architecture.
To generate adaptive behavior, the nervous system is coupled to the environment.
Plant cells respond to abiotic and biotic stimuli, which generate adaptive phenotypes in plant organs.
As Carroll (2008, p. 361) notes, 'both opportunity and catastrophe generate adaptive responses'.
Hybridization may generate new genotypes with adaptive potential that did not reside as standing genetic variation in either parental population, potentially enhancing a population's responsiveness to selection.
Reimagining spatial structure as an adaptive phenotype may generate new insights of both theoretical and practical significance.
