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As the mtDNA haplogroups were characterized by distinct sets of variants, it is not surprising that certain mtDNA haplogroups could affect respiratory chain functions and may further perturb the crosstalk signaling.
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It may therefore be possible that the collagen remains in a pre-gelatinised state that is difficult to distinguish from native collagen without further perturbing the system by attempting to extract the collagen and examine its physical properties or integrity.
Therefore, in accordance with the 'stem cell model' for cancer formation we proposed that a change in the ratio of K-Ras proto-oncoproteins may further contribute to neoplastic progression by perturbing stem cell differentiation [see [ 12]].
For example, given that genomic instability, defective DNA repair, and deregulated transcription are some of the hallmarks of cancer, drugs that further perturb these processes may be specifically toxic (i.e., synthetically lethal) in cancer cells.
This suggests that directed experiments where a particular network or pathway is perturbed and followed over time may further improve the overall performance of a BN approach.
This may further incriminate you.
These mechanisms may explain how LysM2 of Ecp6 may perturb chitin-triggered immune signaling.
Here, we define pVDCs to include compounds that may directly perturb processes fundamental to vascular development.
During development, alterations in the ratio of neurons to glia may severely perturb neuronal function.
In contrast, mutated ERs may moderately perturb the epigenetic network, resulting in global gene deregulation.
The manipulation of cells during their purification may also perturb their methylation profile and gene expression.
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