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Additional blocks at the level of reverse transcription and integration may further impede stable transduction of naïve cells with non-viral sequences, accounting for a nearly eight orders of magnitude difference between the replication efficiencies of constructs with or without specific retroviral cis-elements[10].
This may further impede selective contracting, creating an accessibility-efficiency trade-off.
In addition, the requirement for multiple testing corrections may further impede the discovery of genes with subtle differences in expression.
Distance and transportation issues may further impede or limit access to appropriate care, as occurred in a few cases in our study.
A hydrophobic pocket in the ligand channel of the bovine enzyme may further impede the access of O2 and NO to the active site.
Chronic binge alcohol consumption also has been shown to promote a pro-oxidative and pro-inflammatory milieu (Rashbastep et al. 1993), and these factors may further impede wound healing in patients consuming alcohol prior to experiencing burn injury.
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Teaching science to young learners is challenging (NRC 2007) and may be further impeded by views of developmental limitations of early elementary learners' cognitive abilities and constrained capacity to grasp aspects of abstract concepts (Metz 1995, 2004).
The growth in Type I error as k is increased may be further impeded While there was a slight increase in type I error as k was increased, this is likely to be reduced by introducing an adaptive linkage algorithm.
7 9 All of these factors together further impede access and engagement in screening initiatives.
The "rescue culture" that dominates many surgical ICUs may also further impede such discussions [ 17- 20].
Finally, safety net hospitals typically use Medicaid revenues to help fund uncompensated care; decreases in Medicaid reimbursements may, therefore, further impede hospitals' ability to provide services to the uninsured [ 38].
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