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As alterations in epigenetic regulators frequently lead to genomic instability, DNMT3A mutation may further drive progression of the disease itself (Wakita et al., 2013).
Finally, hypoxia may further drive dependence on ATR in tumors.
In addition, increased plasma NEFA concentrations (as a result of reduced inhibition of hormone-sensitive lipase in type 2 diabetes [ 45]) may further drive ApoB-48 secretion [ 46].
This results in the accumulation of specific (epi genetic changes in the host cell genome that may further drive the progression to a malignant phenotype [ 1, 6].
Furthermore, ZMO1984, a paralogue to ZMO0976, was also upregulated similarly in response to xylose, which may further drive the reaction toward xylitol production.
On the other hand, although biasing potentials, for example, in umbrella sampling, may further drive conformational changes, unless reaction coordinates are properly chosen, it is difficult to interpret the observed changes.
Similar(53)
The process may be further driven close to this sensitive operating point with a controller that manipulates the carbon source feed rate.
This may create a further drive to do well.
The Th1-specific cytokines, IL2, TNFalpha, and IFNgamma, were not upregulated in either of the samples and may suggest that an infectious agent may need to be present to further drive the immune response.
Interestingly, phage related genes were found in pBT and pBGR3 (Figure 2), demonstrating that transduction may also occur between plasmids to further drive genetic diversity by recombination and rapid spreading of new genetic variants adapted to an intracellular lifestyle.
Recent evidence indicates that CXCR3 engagement may drive further recruitment and inflammation, resulting in a positive feedback loop that may contribute to pathogenicity [ 13].
Related(20)
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