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SPRY2 loss may functionally synergize with aberrant cellular signalling to drive PC and to promote treatment-resistant disease.
Indeed, highly diverse consortia of commensals may functionally synergize to derive energy from nutrients in a highly coordinated and efficient manner.
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ARTN and TWIST1 may therefore functionally synergize in aspects of mammary carcinoma cell behavior other than EMT and metastasis reported herein.
An extensive literature, mostly from non-neural cell types, has identified potential mechanisms by which TFs can functionally synergize.
We next tested whether Unc5B and Rnd1 can functionally synergize.
Sequential ChIP, Ring1B depletion, and genome-wide correlations show that PRCs and RNAPII-S5p physically bind to the same chromatin and functionally synergize.
Importantly, all these different NC-RNAs functionally synergize to critically regulate not only the expression of protein-coding genes but also the expression of all other NC-RNAs critical to cancer metastasis.
Alternatively, other Th17-associated cytokines, such as IL-22 [21], may be important or may synergize with IL-17 to control this infection.
This exogenous SPARC may inhibit CML cell proliferation and may synergize with IM activity against CML.
Increased or decreased torsional strain may alter transcription and may antagonize or synergize with chromatin modification and remodeling [ 28].
These mechanisms can operate independently but may also synergize to enhance NK cell sensitivity [7].
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