Sentence examples for may function upstream from inspiring English sources

In this report, it was surmised that LGP2 may function upstream of RIG-I and MDA5 and its adaptor, IPS-1, as a positive regulator of antiviral responses.

Our rationale was that one or more of these genes may function upstream of the inactivation of SBF by Clb/Cdc28, and may, via phosphorylation by Cdc28 mediate positive or negative feedback regulation of Cdc28 activity.

Interestingly, the APC-mutated DU4475 cells, while exhibiting evidence of β-catenin activation and sensitivity to CTNNB1 suppression, were relatively unaffected by CSNK1E suppression (Fig. 3D, E), suggesting that CSNK1E may function upstream of APC in Wnt/β-catenin signaling.

MEK/ERK pathway may function upstream of ROS generation.

A ChIP study suggested that GATA-3 may function upstream of FOXA1.

Since Rac1 stimulates PI3-Kinase activity (Murga et al., 2002), Trio and Rac1 may function upstream of this pathway.

The COM1 may probably function upstream of the ARP2 and regulates its activity.

In a separate study, Wnt5a has been shown to also promote breast cancer cell migration, but in an NFAT-dependent manner, suggesting that Wnt5a may also function upstream and be required for efficient NFAT activation [ 42].

In fact, some recent work has provided evidence that histone demethylases may actually function upstream of transcription factors to create the appropriate chromatin environment for DNA binding [ 76, 77].

Na+,K+-ATPase may also function upstream of other death pathways, as neonatal rat treatment with cardiac glycosides blocks not only autotic death in the CA3 region of the hippocampus, but also other forms of cell death that occur in other regions of the brain.

The results employing the peptide-based caspase inhibitors indicate that caspase-3 and/or caspase-7 plays an essential role in cell proliferation, and that caspase-8, but not caspase-9, may function as an upstream caspase of caspase-3 and/or -7.