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In most bacterial genomes there is one CRISPR array contiguous with the cas gene cluster [9], [11], which has led to the proposal that Cas proteins may function primarily on proximally arranged CRISPRs.
Indeed, there is compelling evidence that migrant RDC may function primarily in antigen transport and delivery to LN-resident DC in the draining LN which in turn are largely responsible for induction of adaptive T cell immune responses [22], [41], [44], [45].
This data indicates that ELK4, unlike SRF and MKL1, may function primarily through promoter-proximal regions.
OmpC is also a generalized porin, but may function primarily under conditions of high osmolarity [ 2].
Distension of these lymphatics and thereby of the overlying tissues may function primarily to inhibit free passage of seminal plasma into the Fallopian tube.
The ubiquitous tissue expression of these serpins indicates they may function primarily in the control of proteolytic cascades such as in prophenoloxidase activation [ 81].
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Islet TNFR2 may therefore function primarily in licensing CD8 cytotoxicity.
Thus, one can speculate that MYOC, a member of the olfactomedin family, may have a function primarily in early eye development, and that its expression in the adult eye is recapitulated only under conditions of stress.
Our current study supports this hypothesis and further suggests that the Tim9 Tim10 hexameric complex may function purely or primarily as a stabilizer for Tim10 subunits.
Although the rats may be functioning primarily as seed predators, they also provide a potentially important backup dispersal system for some species particularly those with multi-seeded diaspores or with seeds that can germinate after partial damage (Pérez et al. 2008).
VosA localizes in the nucleus of mature conidia and its C-terminal region contains a potential transcription activation domain, indicating that it may function as a transcription factor primarily controlling the late process of sporulation including trehalose biogenesis.
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