As DCs are crucial mediators of immune responses by regulating specific T cell responses [7], P-gp may perform its immunomodulatory function predominantly on DCs during DC-induced T cell responses.
Given that disc1 appears to be predominantly expressed in a number of Shh-responsive tissues, we therefore reasoned that disc1 may function downstream of Shh signalling.
Transmembrane mucins may function as cell surface receptors conducting signals leading to responses such as proliferation or apoptosis, whereas secreted mucins are predominantly implicated as a first line of defence for the epithelial surface (reviewed in Hollingsworth and Swanson, 2004).
Another is language, a function predominantly of the left hemisphere.
Although SR proteins predominantly localize in the nucleus, a subset of them shuttles continuously between the nucleus and the cytoplasm, indicating that SR proteins may function beyond splicing (Sanford et al, 2004; Twyffels et al, 2011).
Largely structured proteins are enriched for metabolic functions, while highly disordered proteins function predominantly in regulation.
Instead CX3CL1 was found to function predominantly as an adhesion molecule.
Among them, GATA1, GATA2, and GATA3 express and function predominantly in hematopoietic lineage cells [ 13, 47].
Therefore, we propose that the accumulation of ICP0 in HSV-infected cells (or lack thereof) may dictate whether ICP4 functions predominantly as an activator, or a repressor, of HSV mRNA synthesis.
Though parathyroid hormone per se plays an important role, an acute impairment in left ventricular diastolic function may be predominantly due to elevated serum calcium level but not plasma parathyroid hormone [ 26, 27].
