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We propose that inhibitors of the Wnt/β-catenin pathway fall into two groups: 'constitutive inhibitors' that keep basal levels of β-catenin low, such as members of the degradation complex; and 'inducible inhibitors' that act outside of the degradation complex and may function only when the pathway has been activated.
However, maize-specific miRNAs may function only to regulate gene expression during gramineae- or maize-specific biological processes.
We suggest that soluble forms of hyaluronidases in synovial fluids are not involved in the direct digestion of hyaluronan in joint fluids, because a neutral pH is maintained in synovial fluids, and so hyaluronidase-1 may function only within lysosomes.
It is possible that conserved miRNAs play a key role in universal mechanisms of regulation in different plant species;, however, soybean-specific miRNAs may function only in regulation of gene expression during legume- or soybean-specific processes.
A third possibility is that mir-83 may function only in the DTCs, but that the mir-83 miRNA can be supplied either cell intrinsically or cell extrinsically from muscle-expressed mir-83.
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The fact that the significantly high expressions appeared in eggs, that is Toll genes and an i-type lysozyme gene, suggests that they may function not only in immunity but also in embryogenesis and development.
This suggests that the special clinic may be allowed to function only by permission of doctors, and may buy this consent through the payment of high salary levels there.
Interestingly, miRNAs may function not only as novel biomarkers but also as potential therapeutic targets following cardiac arrest [ 80].
These data suggest that the concept of enhancing chemotherapy activity by adding chemosensitizers may function not only in haematological malignancies but also in selected solid tumours.
Even though the predominant source of irisin is skeletal muscle, it was recently reported that adipose tissue also expresses and secretes irisin, suggesting that it may function not only as a myokine, but also as an adipokine [ 2].
Together with previous results reported by others, our current data raise an interesting possibility that the coupling element CE1 may function not only as an ABRE but also as an element mediating biotic and abiotic stress responses.
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Justyna Jupowicz-Kozak
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