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Modulation of these two mechanisms may function co-operatively to increase antibiotic productivity.
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DNMT1 and DNMT3B function co-operatively to methylate and silence many tumor suppressor genes in colon cancer cells [23].
In proteins, multiple pockets on the same globular domain can also function co-operatively [ 80] (Fig. 2c).
Sp1 is part of a family of transcription factors (Sp1 Sp4) which share highly conserved DNA binding domains and can function co-operatively to regulate transcription of a multitude of genes [ 28].
These extracellular cues may function independently and/or co-operatively with NRG1/ERBB2 signalling cascade to control myelination.
[38] indicates that PMCA functions co-operatively with SERCA and NCX in rabbit aortic endothelium.
Besides a scale-free structure, the network also demonstrated a modular structure; that is, a set of miRNAs and ECs were found to be densely concurrent in community-like modules, suggesting that miRNAs in some functional pathway may be co-operatively "adopted" to respond to ECs [ 34].
Furthermore, it is conceivable that the PH-domain may interact co-operatively with the START-domain and that the concerted action of both domains influences the ligands bound to EDR2 and consequently EDR2 function, as has been observed with the insulin receptor substrate 1 [ 36].
Taken together, these data raise the possibility that multiple phosphorylation sites may work co-operatively to control TBC1D1 Rab-GAP activity and, subsequently, glucose uptake.
Previous studies have suggested that proteins of similar functions may interact with each other to achieve their function synergistically and co-operatively [21], [22], [31].
But a team of Cancer Research UK-funded scientists from the University of Manchester – led by Dr Claudia Wellbrock – has found that these genetically distinct groups of cells may actually work together co-operatively, to break away from the tumour and spread around the body.
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