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Genes, either having direct or indirect network connections to each other, may function closely [21], through signal transduction.
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Firstly, we have identified three closely related paralogues suggesting that these genes may function redundantly.
Further, numerous closely related SJ3 populations harbor differentiated metabolisms that may function to minimize niche overlap, further increasing endemic diversity.
As miRNAs may function as either tumor suppressor or oncogene, deregulation of miRNAs is closely related to tumorigenesis.
Strikingly, we found a list of lncRNAs closely linked to ABCB1 in the Turquoise module (Table 2), indicating that these lncRNAs may function as regulators of ABCB1.
Given our present results, it is not unreasonable to suggest that this function may be closely linked to Podocalyxin's ability to generate microvilli.
They also raised the possibility that LOV1 protein expression is under the control of the circadian clock or that LOV1 function may be closely associated with circadian clock-controlled genes.
Indeed, whole exome sequencing identified mutations in the gene encoding valosin-containing protein (VCP), a key component of the UPS, as a cause of familial ALS, demonstrating that disturbances of UPS function may be closely linked to ALS pathogenesis [ 45].
Since functions in GO are specified at multiple levels of detail, the set of enriched function pairs may contain closely related pairs of functions.
We propose that PDCD10 functions closely with VEGFR2 and PI3K.
In summary, the molecular mechanisms underlying the developmental roles of p53 are emerging, and the developmental roles and tumor suppressive function of p53 may be closely related.
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