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Although moderation and mediation are distinct processes, a variable may function both as a moderator and a mediator in a single functional relation [ 60].
Recently Shao et al [13], [14] reported that Sumo-1, based on immunohistochemical analyses, is expressed in both healthy and atretic mouse granulosa cells in vivo, suggesting that Sumo-1 may function both during follicular development and atresia.
There is evidence that EZH2 may function both as oncogene and tumor suppressor gene.
Indeed, several genes may function both in the catabolism and biosynthesis of starch (e.g., pullulanase [ 48]).
NDEL1 may function both as a cysteine protease and a key centrosomal structural protein.
Opioid peptides are small molecules which are synthesized in vivo and may function both as hormones and neurotransmitters.
Similar(48)
For a cofactor with neither positive fold change nor negative fold change, it may show uniformly high expression, defined by average expression index > 500 at both ES and DF stages, and thus may function at both stages.
Other MG-thyoma increased transcripts included the latrophilin LPHN3, which may function in both cell adhesion and signal transduction, processes that are both essential in tumorigenesis [75].
Furthermore, ISG15 localized in both the nucleus and the cytoplasm suggesting that ISG15 may function in both nucleus and cytoplasm.
The fact that we see both, up- and downregulated genes in C/EBPβ-deficient osteoblasts, supports the notion that C/EBPβ may function as both, activator and repressor in the same cell type and in a gene context specific manner.
Molecular similarity of p68 (an ATP-dependent RNA helicase) with both the large T antigen and eIF-4A (an ATP-dependent DNA helicase) implied that p68 may function as both RNA and DNA helicase [ 20].
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CEO of Professional Science Editing for Scientists @ prosciediting.com