These potentially contradictory effects of IGFBP-5 in bone are further complicated by observations indicating that IGFBP-5 additionally may function in an IGF-independent way, and may have been accentuated by differences in both experimental design and methodology among published studies.
Additionally, PC may function as an indirect mechanism of change during ACT for chronic pain via its direct influence on PF.
Additionally, socket cell DA may function hormonally, as these cells do not express the DA re-uptake transporter.
Additionally, it appears that Pc2 may function differently from members of the PIAS family, which do not appear to require SIMs for E3 activity.
Additionally, recent studies report that LETM1 may function in mitochondrial biogenesis, which is an important feature of human cancer.
Additionally, miRNAs are dysregulated in most tumor types, and may function as either tumor suppressors or oncogenes.
Additionally, expression of both ABCG1 and APOE is regulated by PPARγ (246), and both may function as part of a common lipid trafficking pathway (247).
Additionally, 13%% of GR binding occurs at sites bearing none of the canonical enhancer marks, where GR may function as a true pioneer factor (Fig. 1a).
Additionally, our data indicates that FAK and Pyk2 do not have redundant functions in osteoblasts leading us to hypothesize that Pyk2 may function during long-term mechanical stimulation of osteoblasts.
Additionally, in the brain, unmethylated intragenic CpG islands overlap with the histone modification H3K4me, a marker of active promoters, suggesting that they may function as alternative promoters (47).
