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New adaptive phenotypes may frequently arise first as alternative phenotypes, induced by non-genetic perturbations, and then be genetically stabilized by selection.
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This may partially explain the fact that HCCs frequently arise multifocally (Llovet et al, 2003; Farazi and DePinho, 2006).
Injuries to the extremities may not appear immediately serious; however, latent symptoms frequently arise.
An additional step of stratification and treatment of LKB1-deficient tumours may be to group them with co-mutations that frequently arise in genes such as KRAS and BRG1 (Carretero et al, 2004; Medina et al, 2008).
The data support a model in which ovarian cancers frequently arise within epithelial inclusion cysts, but not the surface epithelium per se, and that carcinoma may be preceded by a dysplastic precursor lesion.
But questions frequently arise when it comes to newer treatments and technologies.
Integration problems frequently arise late in the game.
Issues warranting ethical analysis frequently arise in nursing practice.
Such impacts frequently arise during maintenance, flight operation or in-service events.
As such, conflicts frequently arise between livestock owners, livestock officers, and wildlife managers.
Imbalances of power between the stakeholders frequently arise when actors participate in a coordinated network.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com