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In a set of homologous enzymes, we may find subsets that each contain sequences with one distinct substrate specificity.
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In this situation, one may try to find subsets of trials that do not display heterogeneity and analyse these subsets separately [ 2].
In addition, these analyses may also be done, even in the case of a positive trial to find subsets of patients where the therapy is especially effective or ineffective.
The fact that the 4 patients who did not complete the study were all in the SPTT group raises the possibility that a subset of patients may find this technology intimidating which will need to be considered in planning future studies.
The results shown here are focused on Ewing Sarcoma, but it is extremely likely that they may find a more general application in sarcomas, and in several subsets of other more prevalent neoplasms that depend largely upon IGF1R survival signals (i.e. subsets of lung or breast carcinoma), therefore increasing the potential impact of our findings for sarcoma therapy.
You may find yourself unemployable.
He may find several takers.
Outsiders may find this wasteful.
Some may find it so.
Adults may find this cloying.
Some may find that surprising.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com