The most important function of IgG is to facilitate innate immune mechanisms to microbial challenges the mother has already met.
Here, we address the question of whether specific viral characteristics are common to variants transmitted through breastfeeding that may facilitate evasion of innate or adaptive immune responses.
Interestingly, pneumolysin induced proinflammatory responses in primary macrophages in synergy with TLR2 ligands derived from S. pneumoniae, in particular peptidoglycan and whole pneumococcal cell walls (Malley et al., 2003; Srivastava et al., 2005), suggesting that during infection with intact pneumococci, the combined action of TLR4 and TLR2 may facilitate an optimal innate immune response.
Novel analytical tools and models to study innate immunity may facilitate the development of new gestational age- and sepsis stage-specific therapeutic approaches to fine-tune the premature immune system and thereby optimize the treatment of neonatal infections and sepsis [44].
The PerR-dependent expression of sda1 may facilitate GAS evasion of the host innate immune response.
An association between C. sordellii and the abortion-inducing drug combination mifepristone-misoprostol has been noted; misoprostol may facilitate infection by suppressing the activity of the innate immune system [ 7].
The innate response that occurs after MeV infection may facilitate the development of IL-17-producing cells because IL-6 and IL-1β are increased early, but very little, if any, type I IFN is produced15, 26, 32.
Modulation of the innate mechanisms of facial perception by experience may facilitate the development of adultlike preferences for male faces: experiments have shown that if, among previously-seen faces, a facial feature coexists with a negative stimulus (e.g., a harsh personality), then the observer will develop an aversion for other faces with that feature (Jones et al. 2007).
Repeated stimulation of the innate immune system during chronic or heavy alcohol consumption may facilitate this process, leading to decreased inhibition of the mesolimbic reward system and thus increased drinking (Crews et al. 2011).
Flagellin in cVLPs binds to TLR5 and thus not only can initiate innate signaling to secrete cytokines and upregulate other immune cells but also may facilitate DCs to ingest antigens and then present them to helper T cells [11], [28].
