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The results also suggest that perturbation of the mRNA polyadenylation machinery or RNA processing activity may facilitate generation of iPS cells.
A taut handwing membrane may be a mechanism to avoid an increased drag due to oscillations of a slack membrane (flag effect (Alben and Shelley, 2008)), and may facilitate generation of thrust by the hand wing at the end of the upstroke (Muijres et al., 2011).
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These methods may facilitate robust generation of patient-specific human neurons for in vitro disease modelling or future applications in regenerative medicine.
Recent identification of multipotent progenitor cells in the heart and improved understanding of developmental processes relevant to pluripotent embryonic stem cells may facilitate the generation of specific types of cell that can be used to treat human heart disease.
The recently completed comprehensive profiling of miRNA expression in different tissues [24] will be of great use in determining whether employing the correct combination of miRNAs may facilitate the generation of homogeneous cell populations of desired lineages from ESC.
This recombinational hierarchy may facilitate the generation of genetic diversity within a group and promote specialization between different groups.
Alternatively, ERMES (or its as yet unidentified mammalian equivalent) may facilitate the generation of a constricting force via actin polymerization (Korobova et al., 2013).
This suggests that EMT may facilitate the generation of cancer stem cells with mesenchymal and self-renewal properties required for dissemination and initiation of metastases [ 64].
While H. pylori is the dominant species, the presence of other microorganisms provides a genetic repository which may facilitate the generation of novel traits that influence gastric carcinogenesis.
Reviewer 2 raised questions about how we handled the discussion of evolutionary implications of this study, noting that we do not show examples of how these "off target" biochemical interactions may facilitate the generation of novel cis-regulatory elements.
The microfluidic approach may facilitate the generation of hollow core shell nanoparticles due to the precise fluids control and rapid mixing in small scales,[ 16] but has not been realized yet.
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