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In this light, it is conceivable that subjects bearing higher CCL3L1-containing segmental duplications may express higher levels of chemokines following antigenic stimulus that in turn may increase the risk of developing KD and possibly, IVIG resistance.
Tissue from metastases may express higher levels of growth factor receptors than the primary tumour.
Secondly, there are indications in the literature that cultured cell lines may express higher levels of NQO1 than lung and colon patient tumour tissue [ 14].
There is also evidence that adipose tissue isolated from specific fat depots, such as visceral fat, may express higher levels of inflammatory markers such as IL-6 (7), MCP-1 (8), and plasminogen activator inhibitor type 1 (PAI-1) (9).
Metastatic cancer cells have been found to express exceptionally high levels of TSF (up to 100-fold higher than nonmetastatic cells) [ 77] and it has been suggested that cancer stem cells (CSCs) may express higher levels of TSF [ 78, 79].
Similar(55)
These cells are characterized by expression of the transcriptional factor forkhead box protein 3 (Foxp3) and may express high levels, low levels, or no IL-2 receptor α-chain (CD25); yet they still reveal the same transcriptional signature and potent suppressor function [ 19].
Alternatively, Tregs may express high levels of IL-1R1 simply to compete for IL-1β in the microenvironment, while remaining hyporesponsive to its effects, akin to the constitutive expression of the IL-2 receptor CD25 by Tregs, which has been proposed to deprive nearby T cells of IL-2 signals [35].
This also is true for transfectants that may express high levels of human IL-15Rα [ 98].
Cancers may express high levels of insulin, IGF-1, and hybrid receptors (55), and higher insulin receptor (insulin resistance) expression is associated with worse outcome (56).
Although, in vitro and in vivo studies have demonstrated that hepatoma cells may express high levels of both class I and class II molecules [ 10- 12], little is known about their potential immunogenicity [ 13- 15].
The selection of blast cells via CD34+ sorting is mandatory, because several types of bone marrow cells (such as T lymphocytes) may naturally express high levels of these RIP proteins.
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