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While loss of TH activity may explain variable DA loss in the aged striatum, it is also possible that aging reduces TH protein or activity, and therefore DA bioavailability, in other regions affecting locomotor activity.
Differences between species and anesthesia-analgesia protocols may explain variable findings [ 13].
This observation may explain variable levels of HSPA1 in renal tubules, Bowman capsule and glomeruli, which were detected in our study.
Heterogeneity in clinical experimental conditions (Sorbye et al, 2007), in tumour burden (Köhne et al, 2002) and in genetic/molecular features in the presence of a multisite metastatic disease (Yokota, 2000) may explain variable results in these pharmacogenetic studies.
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The temporal specificity of contralateral dominance may partially explain variable and weak evidence for such dominance in previous studies (e.g. Boch & Goldberg, 1989; Rainer et al., 1998; Everling et al., 2002; Lennert & Martinez-Trujillo, 2013).
As noted above, the preclinical period, from exposure to clinical onset, may be of several weeks, which may in part, explain variable seasonal peaks in different geographic regions [ 12, 13, 16].
This variability may explain the variable clinical responses observed in clinical trials in which IL-17 was targeted (reviewed in [ 27, 36]).
Thus species-specific differences in the regulation of mitochondrial dynamics may exist and may explain the variable deflection of the critical balance between fusion and fission events in different in vivo and in vitro models.
chinensis (Watts) (rFLJ), which may explain the variable medicinal effects.
Consequently, distinct functional aspects of bestrophin 1 may contribute to RPE dysfunction and thus may explain the variable phenotypes associated with a mutant protein.
Further study of these molecular networks may explain the variable response of the developing brain to different types of environmental genotoxicants.
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