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The presence or absence of genes is indicative of unique functions that may explain phenotypic differences.
In particular, the unique expression disparity for the pmpFE operon with relatively high pmpF mRNA levels for 5 of the 6 strains under study, as well as the differential immunoreactivity of patient sera to rPmpD, suggest that some Pmps may explain phenotypic differences among strains for antigenicity, virulence and tissue tropism.
Finally, evaluation of gene-environment interactions may explain phenotypic variation and help identify high risk groups.
Further, several genes in linkage disequilibrium with the met1 region are differentially expressed in the brain during larval development, indicating that more than one gene from the met1 region may explain phenotypic differences between these species.
The dispensable genome, which can account for a large fraction of the entire pangenome, has been shown to harbor genes related to local adaptation, originated by relatively recent horizontal gene transfer events (Medini et al. 2008), and it may explain phenotypic differences found in natural strains (Biondi et al. 2009) and the lifestyle of a given species (Tettelin et al. 2008).
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First author George Perry, a molecular anthropologist who recently moved from the University of Arizona, Tempe, to the University of Chicago, says some of these variants may help explain phenotypic differences between the species.
Genetic diversity and genomic organization may ultimately explain phenotypic variability of the pathogen, including, for example, host specificity, pathogenicity, antimicrobial resistance, and virulence.
These genes all showed line differences at 1d, indicating a possible important role during muscle hypertrophy that may help explain phenotypic differences between the slow-growing randombred line and the line selected for increased 16-wk body weight.
The possible involvement of PSGs in cancer and their genetic variation may in part explain phenotypic divergence that exists in cancer cases with otherwise identical germline mutations.
This may explain the phenotypic variability in TSA treated cloned mice.
This may explain why phenotypic trait means may not well correspond to (directional) selection acting on them.
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