Genetic differentiation between our experimental cohorts is comparable to that between human populations, suggesting in turn that our results may help explain heterogeneous signals in human association studies of extreme longevity when panels have diverse ancestry.
This may partially explain heterogeneous findings from Quibdo and San Jose de Guaviare, in which there were differences in recall on violence experienced in displaced settings compared to recall of conflict-related violence that may have occurred more distally in time for some.
However, both different intensities of selection and unequal levels of gene conversion may explain the heterogeneous mismatch distributions observed among the loci.
We explored age and age-related factors that may explain the heterogeneous associations of BPA between the two cohorts.
Where the balance lies in these antagonistic effects is likely to vary and may explain the heterogeneous angiogenesis seen in pancreatic disease.
This is interesting because it suggests that DNA methylation changes explains much more of the homogeneity in the transcriptomic differences observed between luminal-A and luminal-B breast cancers, whereas copy number changes may explain more of the heterogeneous differences.
Therefore, the VC group in other studies was actually heterogeneous, which may explain discrepant observations.
Nevertheless our finding that s-BOTs and associated implants are heterogeneous lesions may explain a different clinical presentation of s-BOTs and implants and might encourage to applying more individualized follow up protocols.
This increased filament length in the heterogeneous model may explain why, on average, slightly fewer filaments were seen relative to the homogeneous model (Table 2), as the longer filament lengths would reduce the number of reentrant circuits and scroll waves that could fit within the confines of the rabbit ventricular geometry (5, 31, 39).
The heterogeneous expression levels may explain nonresponse to anti-IL-17 therapy in subsets of patients.
