Since N can bind RNA non-specifically, this result may explain the specificity for genomic RNA in promoting virus release.
However, the motif itself may be a source of bias, which may explain the differences in genomic distributions among motifs (e.g., underrepresentation of GC-rich STRs; Toth et al., 2000; Katti et al. 2001).
Overall, GLI2ΔN-expressing keratinocytes are resistant to both chromosomal alteration-mediated and UVB/DNA-damage-induced apoptosis, and this may explain how cells with genomic aberrations are able to escape apoptosis and give rise to CIN.
This projection of current genomic relationships towards the relationships between founder animals by SSGBLUP will be especially unrealistic for deep pedigrees, in which many alternative inheritance patterns may explain low or high genomic relationships between animal pairs, and founder animals are separated by many generations from the current animals.
The insertion in a less favorable genomic context may explain why some NUMTs (like NUMT20) where not found to function as chromosomal replication origins, at least under the tested conditions.
Likewise, viral genomic variation may explain treatment failure in some individuals.
An emerging picture thus indicates that different forms of genomic variations may explain some of the expected genetic risk for a group of individuals [ 10, 11, 17].
Loss of orthologous copies may result in paralogues rather than orthologues being compared in genomic analyses, and may explain why comparative mapping sometimes suggests anomalous synteny relationships across genomes (Paterson et al., 2004).
Additionally, comparative genomic analysis was conducted among PCN033 and other nine characteristic E. coli strains to identify genomic differences that may explain the ability of PCN033 to cause disease in the pig host.
Furthermore, certain replication timing changes can directly lead to overt genomic instability and may explain unique mutational signatures that are present in cells that have undergone the recently described processes of "chromothripsis" and "kataegis".
