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Moreover, the aforementioned secondary protease-antiprotease imbalance derived from neutrophil degranulation may explain focal alveolar epithelial and endothelial cell destruction leading to emphysema [ 36].
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This mechanism may explain why focal electrical stimulation of the entorhinal cortex in patients with seizures leads to an enhancement of memory performance (Suthana et al., 2012).
Different contributions of periportal and pericentral autophagy may explain the observed focal rather than global distribution of lipid droplets.
Interestingly, we also show that MVL-PLA2 enhances microtubule dynamics likely leading to the alterations in the formation of focal adhesions, which may explain its effect on angiogenesis.
Furthermore, paxillin was not detectable by immunostaining (Fig. 5H) indicating lack of focal adhesions, which may explain the observed weak adherence to substrate in this cell line.
We propose that the enhancement of microtubule dynamics may explain the alterations in the formation of focal adhesions, leading to inhibition of cell adhesion and migration.
Possible compensation by other tensins may explain why DLC1ΔPTB can be localized to focal adhesions in the absence of tensin2 interactions.
As focal adhesions predate AJs (Sebé-Pedrós et al., 2010), inclusion of these components in cell matrix adhesion may explain the pre-metazoa role of some cell cell adhesion components.
Furthermore, the down-regulation of talins (actin and integrin binding proteins) may explain per se the misalignment and apparent failure of adhesion observed in the mATX3-depleted cells given their key role in focal adhesions and cell spreading [52].
Those factors may explain something.
That may explain why!
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