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Docking studies reveal the possibility of both hetero- (S-Cit + 5-HT) and homo-dimeric (5-HT + 5-HT) co-binding at both these sites which may explain earlier published allosteric activity observations and provide novel design strategies.
This finding may explain earlier report of why EGFRvIII expression rarely occurs without EGFR gene amplification [ 4].
These findings may explain earlier findings of positive effects after psychosocial intervention on family caregivers' sense of burden, satisfaction, and ability to delay nursing home placement.
This shift in mutational spectra may explain earlier observations of accelerated gene loss near the origin and contribute to ongoing elevation in indel rates in that region.
Peripheral conversion of adrenal androgens to estrogens may explain earlier breast development independent of changes in ovarian hormones in recent birth cohorts [ 55] and isolated breast development that occurs without activation of the HPO in some girls [ 56].
Humoral defects exist (both in antibody responses and complement opsonisation) and may explain earlier reports of a defect in phagocytosis, but are poorly studied in the pathogenesis of sepsis.
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These sources of variability may explain early controversies in the literature when new markers are described by different groups.
The low homology between the two proteins may also explain earlier immunoblotting experiments that demonstrated weak immunological cross-reactivity between the two species that became apparent only following protein reduction and alkylation, which may have unfolded hidden homologies [61].
A shared disease pathway may help explain earlier reports of individuals who demonstrate an "overlapping" neurodegenerative syndrome combining Parkinsonism and NCLs [ 72– 76].
Exposure of adult male rats to PFOA reduced their testosterone levels and increased their estradiol levels, which may partly explain earlier findings of induction of Leydig cell hyperplasia and/or adenomas in the testes of exposed animals (Biegel et al. 1995; Cook et al. 1992).
The factors that may help explain early retirement among GPs are further described in the methods section of this article.
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