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This suggests that the misaligned mice may experience sleep compensation, and have shifted "consolidated" sleep to the nighttime.
Intuitively, a stimulant with a duration of action lasting into the evening following a single morning dose might be expected to be associated with sleep-related TEAEs yet, paradoxically, patients receiving shorter-acting formulations may experience sleep disturbances due to a rebound effect in the evening after their medication wears off [ 49].
If you're still and silent long enough, you may experience sleep paralysis.
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Narcoleptics may also experience sleep paralysis, which normally occurs as one is either falling asleep or awakening.
Such patients may also experience sleep disturbances, which have been associated with headache exacerbation.
13 20–22 Yet, in some circumstances, stimulants may improve sleep 26 and many stimulant naïve children also experience sleep problems, 5 therefore other factors have received increasing investigation.
Waking to experience sleep paralysis is a sign that your body may not be making smooth transitions between the stages of sleep.
Students with an irregular bedtime schedule may experience poor sleep quality.
After discharge from the ICU, patients may experience altered sleep patterns, anxiety, depression [ 6, 7], disorientation, mood changes [ 8], and lapses of memory and concentration [ 9, 10].
Younger participants may be more likely to experience sleep difficulties and decreased appetite as AEs with stimulant treatment at high dose levels [ 23].
While you may be experiencing sleep deprivation, weight gain and swollen feet, someone with infertility longs for the day their pregnancy and child brings about these challenges.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com