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The top scoring motif was as expected the known SOS box consensus sequence, but the novel motifs indicate that other regulatory sequences may exist upstream of genes upregulated due to UV irradiation, as discussed below.
A stimulation by ABMP also exerted opposite effects on IFN-α levels between IQI SPF and BALB/c mice suggesting an additional, strain-specific regulatory pathway(s) may exist upstream of the ISGF3 complex.
Mutation of the ARE significantly inhibited luciferase induction; partial inhibition may have been due to other factor(s) induced by Nrf2 or cryptic ARE site, which may exist upstream of 3 kb (analysis using rVISTA 2.0 prediction algorithms showed only one ARE site within ∼3 kb).
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While the present study does not reveal significant wealth inequalities in uptake of cataract surgery among those eligible, wealth inequalities may exist further upstream in the process [ 6, 7].
TATA-box motifs also frequently exist upstream of genes downregulated by Fe deficiency (Figure 4E).
Consequently, natural differences in river reaches commonly exist upstream versus downstream from dam sites.
Finally, no other large dam could exist upstream of the focal dam prior to its construction.
These variations should only belong to the accessions of HA in Q4 subpopulation, and may exist in the upstream or promoter region of HvLDI, or the regulated factors, which co-segregated with the detected SNPs.
In this study, we have indentified that IP3R1 and IP3R2 may exist, at least in part, upstream of calcineurin/NFATc signaling during heart development.
Previous work has identified several genes that are co-expressed in both neurosensory primordia in the ear as well as delaminating and differentiating sensory neurons outside the ear, indicating that common upstream regulatory elements may exist for these topologically distinct cells that apparently differentiate into unique adult cells [6], [7], [8], [9].
Meanwhile, alternative pathways may exist for TSA or AzadC that affect their upstream regulators genes, which also regulate the expression of these genes.
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