However, several recent studies (reviewed in [11]) pinpointed exquisite differences among Hsp70 orthologs suggesting that while they share redundant house-keeping functions, they may exhibit functional specificities that have yet to be fully deciphered.
The modular Ig-like domain repeats allow binding to a large number of host proteins since each Ig-like domain may exhibit different specificities.
Though many binding sites exhibit specificity required for their biological function, other molecules require less specificity to fulfill their purpose.
The frequent replacement of wild-type amino acids by proline at major protease cleavage sites indicates that at least pepsin- and chymotrypsin-like enzymes may exhibit a (conformational) specificity concerning the P1 and P2 positions.
Similar to SIRT6, SIRT1 3 may exhibit context-dependent specificity toward certain acylation on Lys residues.
Furthermore, evidence suggests that edited miRNAs may exhibit different target specificity compared with their nonedited counterparts (Ekdahl et al. 2012).
However, the outbreaks of severe acute respiratory syndrome (SARS), a serious zoonotic transmission event caused by a novel coronavirus, demonstrate that a certain coronvirus species may exhibit wider host specificities and suggests the possibility of cross-species transmission of animal coronaviruses to human [3], [4].
They may be involved in NER in Archaea and Eukaryota, like their postulated Bacterial orthologs from the UvrC/Cho family, and they may exhibit different substrate specificities, in analogy to the functional divergence between UvrC and Cho.
As modifications of MFO activity may alter the toxicity of chemicals, these findings suggest that the toxicity of chemicals may be altered in animals exposed to PBBs and that these toxicities may exhibit age, sex, and organ specificities different from those seen in control animals.
Our data showed that even for these genes with the same tissue specificity by mRNA level expression analysis, they may exhibit difference in their expression patterns in tissue/cell level.
