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For the first time in literature, we show that primary colorectal cancer and paired metastasis may exhibit difference with respect to EGFR pathway deregulation mechanisms possibly implying a different response to cetuximab or panitumumab treatment.
Our data showed that even for these genes with the same tissue specificity by mRNA level expression analysis, they may exhibit difference in their expression patterns in tissue/cell level.
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The Kd (affinity) and dynamics of different protein protein/ligand or peptide interactions vary widely; hence different PIC reagents may exhibit differences in reactivity, product distribution, and yield depending on the system.
Some studies only assessed appropriate empiric therapy for MRSA, some included all sterile sites of infection and all studies were from geographically diverse areas which may exhibit differences in antibiotic prescribing, antibiotic resistance trends and differing patient populations.
Enantiomers of the same pharmaceutical have identical physicochemical properties, but may exhibit differences in pharmacokinetics, pharmacodynamics and toxicity.
Patients receiving pazopanib may exhibit differences in tolerability when compared to individuals treated with the other approved anti-VEGF TKIs.
Isoforms of the same enzyme may exhibit differences in transcriptional regulation, and mRNA concentrations do not account for post-translational modification of enzymes.
These observations suggested that vocalisations are spectrally stable among vervet subspecies and between vervet and tantalus (Chlorocebus tantalus) populations, but that they may exhibit differences in temporal characteristics (Struhsaker 1970).
However, since dietary behaviors significantly differ between mice prolonged fed with HFD and hyperphagic mice fed with normal diet (ND), they may exhibit differences also in molecular response to the deposition of a body fat.
To examine genes that may exhibit differences in basal expression between NBH and SC embryos, we performed a pairwise comparison of the control (DMSO-exposed) fish from each site at each time point.
By implementing appropriate coculturing techniques, and ensuring that suitable compounds are present in the media, we may be able to maintain chemical features of cultured neurons that are comparable to freshly isolated cells; or these neurons may exhibit differences, such as distinct neurite development and chemical connections between cells.
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