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The cancer cells under sustained ROS stress tend to heavily utilize adaptation mechanisms and may exhaust cellular ROS-buffering capacity.
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This observation is in line with the recently developed concept that overloading stress may exhaust the cellular stress response pathways thereby sensitizing cancer cells to chemotherapy [ 5].
Such prolonged exposure may have exhausted cellular defence mechanisms hence resulting in cell death.
And their negotiation may exhaust political capital that could be better spent on global efforts.
This simple technology may be used to create reconfigurable interfaces that allow users to selectively discard contaminated or exhausted cellular sensor elements, and to replace them with new living cellular components for continued operation in future biomedical microdevices and biodetectors.
It was suggested that inhibitor efflux and detoxification exhaust cellular energy, thereby inhibiting growth and biofuel production (30).
Although cancer genesis may thus be controlled by these mechanisms, the long-term stress caused by cobalt and chromium ions may eventually exhaust these functions, which may lead to cellular senescence and apoptosis and eventually to a functional failure of the affected organs.
Therefore, further oxidative insults, such as the exposure to ROS-generating agents, could exhaust the cellular antioxidant capacity and cause severe accumulation of ROS, leading to cell death.
During this time, the villagers may eventually exhaust one sheep's food.
If you are out of shape, your first few days and weeks may totally exhaust you.
By 11pm, they may be exhausted.
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CEO of Professional Science Editing for Scientists @ prosciediting.com