Sentence examples for may exert significant from inspiring English sources
"Large-scale sales by funds may exert significant downward asset-price pressures, which could affect the entire market and trigger adverse feedback loops," it warns.
Dewatering associated with mining below water table to achieve dry mining conditions may exert significant pressure on water balance in terms of lowering the water table and change in the dynamics of interactions between surface water and groundwater.
Some experimental and clinical studies suggest that these drugs may exert significant pleiotropic effects, in particular on chronic kidney disease (CKD) progression, but data from clinical trials are still controversial.
These studies suggest that aspirin may exert significant anti-inflammatory effects by suppressing the production of macrophage-derived inflammatory mediators.
In addition, BAF60b may exert significant impacts on whole body energy homeostasis by regulating the development and function of the immune system and meta-inflammation.
Like for any drug which has inconsistent effectiveness and may exert significant harm, the correct fluid management should include a cautious and comprehensive assessment of fluid-induced benefits and side effects.
Therefore, Tregs in TNBC may not exert significant suppression on CTLs.
However, in the triple negative cohort assessed in our study, fewer than 20% of CD4+FOXP3+ lymphocytes were in direct contact with CD8+ TIL (data not shown), suggesting that Tregs in ER– breast tumours may not exert significant suppression on CTLs.
Furthermore, it remains to be verified whether the combination of MEK or PI3K/mTOR inhibitors with death receptor agonists (such as TRAIL itself or DR5-specific mAbs) may also exert significant pro-apoptotic effects in vivo on melanoma xenografts and whether this is associated with inhibition of relevant pro-tumoral processes in the tumor microenvironment.
The authors concluded, "These very low effective doses for xenoestrogens demonstrate that many environmental contamination levels previously thought to be subtoxic may very well exert significant signal- and endocrine-disruptive effects, discernable only when the appropriate mechanism is assayed".
These very low effective doses for xenoestrogens demonstrate that many environmental contamination levels previously thought to be subtoxic may very well exert significant signal-and endocrine-disruptive effects, discernable only when the appropriate mechanism is assayed.
