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However, stearoyl LPC also confers protection against lethal endotoxaemia (Ref. 129), implying that it may exert protective effects through an additional, bactericidal-independent mechanism (Ref. 130).
We hypothesized that a single administration of Asiatic plantain beverage may exert protective effects against postprandial oxidative stress.
Fenbendazole may exert protective effects through multiple possible mechanisms, one of which is inhibition of the proliferation of B lymphocytes, thereby reducing antibody responses.
These results suggest that low-dose aspirin may exert protective effects against cerebrovascular inflammation and damage by salt loading through down-regulation of superoxide production and induction of nitric oxide synthesis.
Recent data have shown that peroxisome proliferator-activated receptor-γ agonists may exert protective effects on the vascular endothelium by amelioration of insulin resistance and through direct anti-inflammatory effects.
Previous pre-clinical studies, from our group and others, have demonstrated that HCA may exert protective effects in models of ARDS induced by free radicals [7], endotoxin [8], both primary [9, 10] and secondary [11] ischemia-reperfusion, and high lung stretch [12, 13].
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Acetyl-L-carnitine infusion may also exert protective effects on the injured cells [ 80].
Whether SK2 channels may also exert protective effects in differentiated neurons has not yet been reported.
Since A2MG microparticles contain a number of proteins (Dalli et al, 2013) that may also exert protective actions we next constructed synthetic microvesicles that were selectively loaded with a defined amount of A2MG (A2MG-MV; see Materials and Methods for details) and tested them in murine sepsis.
Recently, silibinin, a polyphenolic compound contained in silymarin, has been demonstrated to exert in vitro protective effects on endothelial cells [ 5]; however, it is not clear whether silibinin may exert vascular protective effect in vivo.
However, either AMPK agonists or inhibitors may exert the protective effects via AMPK-independent ways.
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