Sentence examples for may exert profound from inspiring English sources

Such alterations may exert profound effects on neurodevelopment, potentially persisting throughout the lifespan.

It has been established that altered DNA methylation at critical regions of a master regulatory gene may exert profound effects on the expression of many downstream target genes (Lukens and Zhan 2007; Chinnusamy and Zhu 2009; Doerfler 2011).

These data supported the hypothesis that S100/calgranulin and HMGB1 ligands may exert profound effects on cellular phenotype [ 15].

Of note, experimental evidence indicates that proteasomal inhibitors like bortezomib may exert profound antiinflammatory activities in kidney diseases, like lupus nephritis [ 50] and necrotizing glomerulonephritis [ 51].

These results imply that alterations of the cell-cycle checkpoint controlling proteins p27KIP1, p16INK4a, and RB1 may exert a profound effect in malignant transformation in BPDCN.

The mechanisms responsible for this failure are largely unknown but the kinetics of hepatitis C virus replication relative to the priming of the adaptive responses may exert a profound influence on the balance between virus and host.

In depressive disorders, galanin may exert a profound inhibition of dorsal raphe neuronal activity, partly mediated via galanin/5-HT1A receptor interactions, which may result in a dysfunction of 5-HT neurotransmission in the cortico-limbic areas of the brain associated with depression.

We hypothesized that the degree of mismatch between donor and host may exert a profound effect on their immunosuppressive properties.

Thus, the SGTP introduced by thiopurine drug treatment may exert a profound effect on CDK activity, which may ultimately affect cell cycle progression.

Such compounds also are likely to exert profound effects on mood, thought, and observable behaviour.

Similarly, sedatives and analgesics exert profound effects on immune cell function [80, 81].