These data suggest that environmental contaminants may exert effects on neuronal function both by direct inhibition of sulfotransferase enzymes and by interrupting the supply of PAPS, which has wider implications for endocrine disruption and xenobiotic metabolism.
That might be because WT TET1 may exert an opposite effect on neuronal differentiation in an enzymatic activity-dependent manner.
These observations suggest that CNS maturation, synaptogenesis, and associated processes may exert a unique stress on neuronal circuits.
Analysis of the transcriptional profile of hMSCSYT-SSX1 revealed overexpression of genes related to nervous system development, suggesting that SYT-SSX1 may exert some degree of pressure toward neuronal differentiation in mesenchymal stem cells.
However, astrocytic Ca2+ waves also occur spontaneously in vitro and in situ [28], [50] so it is important to note that they may exert a guidance function in the absence of neuronal activity.
The above studies suggest that cell cycle proteins might directly interact with the neuronal cytoskeleton, and that they may exert their effects by modulating specific functions of other regulators of cytoskeletal dynamics, such as CDK5 or SPAR.
Because no obvious neuronal cell death was detected in either the kindled WT or Fmr1 KO mice 24 h after the completion of kindling development, this enhanced axon reorganization indicates that FMRP may exert an important role in preventing activity-induced neuronal network reorganization in the adult brain.
Thus, our data linking Ack1 to neurotrophin signaling together with the observation that its expression is regulated by neuronal activity suggest that Ack1 may exert a further potential role in synaptogenesis and synaptic plasticity events that would be addressed in future work.
These results show for the first time that inhibition of the PDE7 enzyme leads to dopaminergic neuronal protection and therefore its inhibitors may exert useful therapeutic actions in patients with PD, a hypothesis that is amenable to clinical testing.
Hence, the antioxidant activity of Sesns may exert a neuroprotective role during aging as well as upon neuronal injury.
