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In addition, Wnt/β-catenin signaling may exert distinct functions in a dose dependent manner.
The change of the arginase isoform according to polarization could allow each MØ type to distinctly address arginases to the cytosolic (Arg I) or mitochrondrial (Arg II) subcellular compartments where they may exert distinct biological effects as reported in endothelial cells [18].
Our results demonstrate that different nanoparticles may exert distinct biological effects.
Nevertheless, here-to-fore unrecognized miR-16 targets may exert distinct, yet crucial functions during cell differentiation.
Hence, MKK4 and MKK7 may exert distinct effects on embryogenesis through differential activation of JNK and p38.
The need to consider the effects of buffering HCA is emphasized by the fact that both hypercapnia and acidosis per se may exert distinct biologic effects.
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In addition, as illustrated also by our results in the K/BxN serum transfer-induced arthritis model, IL-1 and IL-36 may also exert distinct effects in the control of local inflammatory responses in the joint.
Nevertheless, aPS/PT antibodies may exert their distinct pathogenic role through pathways in which PAF-AH is not involved.
Thus, Ob-R is expressed in placenta throughout gestation in mice and bats, and its expression increases over the course of gestation, which raises the possibility that leptin may exert temporally distinct effects on placental growth or function throughout gestation.
This finding suggests that p17 derived from divergent HIV-1 strains may exert a distinct biological activity on B cells and possess a different pathogenetic potential.
Given that DR5 expression levels do impact patient prognosis as demonstrated in this study, our data suggest that it may be interesting to study whether membrane-bound and cytoplasmic DR5 proteins exert distinct functions (e.g., apoptotic vs. non-apoptotic) under different conditions.
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