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The results suggested that tissue factors may exert direct effects on the intensity and direction of the natural selection on enhancers.
In combination, the results of the present study suggest that factors associated with functions or characteristics of the tissue may exert direct and profound effects on the intensity and direction of the natural selection applied to regulatory DNAs, such as enhancers.
Contaminants may exert direct effects on keystone facilitator and foundation species, and contaminant-induced changes in nutrient and oxygen dynamics may alter ecosystem function.
Nicotine's enhancement on each respective measure was not task-content specific in either sample.These data suggest that acute nicotine administration may exert direct beneficial effects on novelty detection and subsequent memory recognition in both smokers and nonsmokers.
However, the authors were skeptical about these instruments, pointing out that family background may exert direct effects on earnings, and ability may show intergenerational persistence (Hanushek et al. 2015, p. 119).
The main reasons for this are those discussed in the literature on returns to years of schooling: schooling is a choice variable, family background may exert direct effects on earnings and employment, and ability may show intergenerational persistence (Card, 1999).
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Alternatively, MuRF1 and MuRF2 may also exert direct effects on lipid metabolism, as enoyl-coenzyme hydratase I (interacting with both MuRF1 and MuRF2; see Figure 3A; for review, see Kim and Battaile, 2002) participates in the β-oxidation of lipids.
Androgens may also exert direct AR-dependent effects on adipocyte differentiation and function (45), and hyperinsulinemia and visceral obesity are reported in male mice lacking the AR in adipose tissue (46), although others found no similar phenotypes (47).
8 9 Besides being associated with lower acute rejection rates as compared to azathioprin, 10 11 evidence from animal and human studies suggests that MMF may also exert direct antifibrotic properties due to its antiproliferative action on non-immune cells, including renal tubular cells and vascular smooth muscle cells.
A central issue in the debate is whether a noncognitive factor, such as affect, may exert a direct influence on attitude, or whether its influence is mediated by the cognitive structure.
When more than one cell type is found within a single endocrine gland, the hormones secreted by one cell type may exert a direct modulating effect upon the secretions of the other cell types.
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