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Using λS of 1.4 as the cutoff may exclude genes with modest effects.
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This may be useful to exclude genes that are potentially post-transcriptionally regulated.
This latter approach has the potential to exclude genes that may be important in differentiating sepsis subtypes, rather than differentiating sepsis from controls.
In addition, the criteria of a threefold change in gene expression may exclude biologically important genes with expression that falls into the 'noise' range.
Too much filtering may exclude some important genes, whereas too little filtering will reduce power by increasing the number of tests performed.
This single step removal of contigs that match non-parasite at some e-value may exclude ancient, highly conserved genes that return high similarity against both parasite and non-parasite.
Candidate genes, based on putative physiological roles, may exclude the identification of novel genes or pathways that influence the target traits [ 5].
The proposed approach can only detect polymorphic host factors that leave an imprint on the virus, which may exclude mediators of immunopathogenesis or genes involved in the establishment of tolerance (Medzhitov et al., 2012).
For example, researchers may exclude taxa lacking data for some genes or exclude a gene lacking data in some taxa.
20 Hence, the analysis may exclude the involvement of a gene in a process.
This may exclude Thomas from certain reckonings.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com