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The inflammatory response may exacerbate tissue damage, but is not essential for skin wound healing [37].
Under some circumstances, pro-inflammatory responses to intracellular DAMPs may exacerbate tissue injury, whereas under other conditions DAMPs may elicit cytoprotective responses.
By mediating autocrine activation of local endothelial cells, Ang-2 may exacerbate tissue hypoperfusion and inflammation, providing a plausible mechanism for its independent association with organ failure and mortality in sepsis [ 7].
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let-7 overexpression in these contexts would probably not elicit growth suppression, but may instead exacerbate tissue injury.
Overexpressing let-7 in those contexts would probably not suppress growth, but may instead exacerbate tissue injury.
While persistent hypoperfusion after burn trauma would produce cell death, volume resuscitation may exacerbate the tissue injury that occurred during low flow state.
The control reconstituted human epidermal (RHE) tissue was selected as it is representative of a normal keratinizing epithelium, comprised of basal cells, spinous keratinocytes, granular keratinocytes with basophilic keratohyaline granules, and keratinizing cells, yet without the capacity for recruitment of inflammatory cells that may exacerbate host tissue damage (Fig. 6A).
Secondary occlusal trauma occurs in teeth with pre-existing periodontitis, and may exacerbate periodontal tissue breakdown.
Several studies have found that the inflammatory microenvironment following alcohol exposure and/or trauma may allow neutrophils to exacerbate tissue damage in numerous organs including intestine (Amin et al. 2007 a, b ; Bird and Kovacs 2008; Li et al. 2007, 2008 a, 2011).
This stress-concentration would exacerbate tissue damage in the area surrounding the collapse [33].
We further hypothesized that high dynamic strain would exacerbate tissue damage in ALIT.
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