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Even more importantly, axonal degeneration may even precede and sometimes cause neuronal cell death (Coleman, 2005).
On the other hand, diabetic glomerular lesions may even precede the onset of albuminuria [ 11].
Early alterations in the extracellular matrix also occur in the stroma, some of which may even precede epithelial alterations [ 5].
Anti-Jo-1 autoantibodies are usually present at the time of diagnosis and may even precede the development of myositis symptoms [ 40].
Diffuse cutaneous systemic sclerosis (dcSSc) is less common, associated with ATA, and an extensive skin involvement and pulmonary fibrosis often parallel or may even precede Raynaud's phenomena.
Nonalcoholic fatty liver (steatosis) and hepatic insulin resistance are typical for type 2 diabetes and may even precede or contribute to its development (2, 3).
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All these changes may parallel, or even precede, species diversification (Elder and Turner, 1995; Koukalova et al., 2010; Raskina et al., 2011; Belyayev and Raskina, 2013).
It may even have preceded her birth.
Obviously, this neuron loss may be accompanied, or even preceded, by other signs of neuropathology, such as synapse loss (Moechars et al. 1999; Pratico et al. 2001).
While the exact pathogenic contribution of these two AD hallmarks and their abundant constituents [aggregation-prone amyloid β (Aβ) peptide species and hyperphosphorylated tau protein, respectively] remain debated, a growing body of evidence suggests that their development may be paralleled or even preceded by the alterations/dysfunctions in the endolysosomal and the autophagic system.
Malignant lymphoma, which accounts for less than 1%% of all brain tumours, may be associated with or even preceded by demyelinating lesions.
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