"By definition, they act without direct command and control from a wider network, and it is assumed that without such communications they may evade the 'tripwires' that would usually bring them to the attention of the authorities".
In addition, it would be possible to kill oncospheres as well as early cysticerci, which may evade the initial immune attack.
However, HCV may evade the IRF1 anti-HCV effect through core-mediated suppression of IRF1 synthesis.
This mechanism may evade the effect of multidrug resistance proteins, present in cancer cells [ 17, 18].
At more advanced stages of malignant transformation CSCs may evade the immune system, induce angiogenesis, and finally acquire metastatic capacities.
Thus, aberrant expression of B7-H1 has been postulated as a potential mechanism by which malignant tumors may evade the host immune response.
Additionally, cancer cells may evade the immune surveillance of complement-mediated lysis by expressing membrane-bound and soluble complement inhibitors, including Factor H [28].
Cooperative activation of different ErbB family members through heterodimerization may evade the therapeutic efficacy of inhibition of a single receptor target which, for example, may in part explain the relatively low response rates with trastuzumab.
It has been demonstrated that during bevacizumab therapy tumors may evade the inhibition of VEGF signaling and so the association of a cytotoxic drug might lead to more effective treatment.
Additionally, many chemotherapeutic agents inhibit the biogenesis of ribosomes (Killian et al, 2004), so downregulating these proteins may evade chemotherapy.
