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At low doses, cells may escape cell-cycle arrest and continue cycling normally.
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This pattern of results is consistent with the view that the SU-DHL-4 cells are escaping cell-cycle arrest at the 24 h measurement point.
Recent evidence indicates that alternative mechanisms, such as cell-cell fusion, may also render cells with the ability to escape cell cycle control, tissue invasion, and metastasis [ 10].
Thus, CD138low cells escape cell cycle arrest induced by X-irradiation, suggesting intrinsic resistance of these cells.
The subpopulation of senescent cells, characterized by high surface CAR expression, retains the ability to escape cell cycle arrest.
These senescent cells persist for up to 3 weeks, during which infrequent cells escape cell cycle arrest to form proliferative colonies.
P16INK4 a is a specific inhibitor of CDK4 and 6, and thus, inactivation of p16INK4 a allows cells to escape cell cycle arrest in G1.
Tumors with germline BRCA mutations accompany the capacity to escape cell cycle checkpoints, which is in accordance with the low incidence of mutant BRCA-mediated sporadic tumorigenesis.
Also if this were the case, then the stalled cells would not be able to escape the cell-cycle arrest.
These tumor cells may escape CTL attack and attack by a subset of NK cells.
At the uptake stage, it has been previously shown that some bacterial cells may escape mechanical degradation by the pharyngeal grinder (32), with small cells potentially escaping more easily (33).
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